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1

Mechanisms of Chemical Carcinogenicity and Mutagenicity: A Review with Implications for Predictive Toxicology

Benigni, Romualdo, Bossa, Cecilia

Journal:

Chemical Reviews

Year:

2011

Language:

english

File:

PDF, 4.27 MB

english, 2011

2

Nongenotoxic Carcinogenicity of Chemicals: Mechanisms of Action and Early Recognition through a New Set of Structural Alerts

Benigni, Romualdo, Bossa, Cecilia, Tcheremenskaia, Olga

Journal:

Chemical Reviews

Year:

2013

Language:

english

File:

PDF, 4.33 MB

english, 2013

3

Establishing the level of safety concern for chemicals in food without the need for toxicity testing

Schilter, Benoît, Benigni, Romualdo, Boobis, Alan, Chiodini, Alessandro, Cockburn, Andrew, Cronin, Mark T.D., Lo Piparo, Elena, Modi, Sandeep, Thiel, Anette, Worth, Andrew

Journal:

Regulatory Toxicology and Pharmacology

Year:

2014

Language:

english

File:

PDF, 2.24 MB

english, 2014

4

Tumor profiles and incidence in Europe: Robustness of spatial patterns of correlation, and their relation with allele frequencies of the ABO blood group system.

Benigni, Romualdo, Giuliani, Alessandro

Journal:

Journal of Environmental Science and Health Part C

Year:

2000

Language:

english

File:

PDF, 1.29 MB

english, 2000

5

Data-based review of QSARs for predicting genotoxicity: the state of the art

Benigni, Romualdo, Bossa, Cecilia

Journal:

Year:

2018

Language:

english

File:

PDF, 355 KB

english, 2018

6

In silico models for genotoxicity and drug regulation

Benigni, Romualdo, Bassan, Arianna, Pavan, Manuela

Journal:

Expert Opinion on Drug Metabolism & Toxicology

Year:

2020

File:

PDF, 758 KB

2020

7

Quantitative structure-activity relationship (QSAR) studies of mutagens and carcinogens

Romualdo Benigni, Alessandro Giuliani

Journal:

Medicinal Research Reviews

Year:

1996

Language:

english

File:

PDF, 1.25 MB

english, 1996

8

QSAR models for discriminating between mutagenic and nonmutagenic aromatic and heteroaromatic amines

Romualdo Benigni, Laura Passerini, Grazia Gallo, Fabrizio Giorgi, Marina Cotta-Ramusino

Journal:

Environmental and Molecular Mutagenesis

Year:

1998

Language:

english

File:

PDF, 107 KB

english, 1998

9

ChemInform Abstract: Quantitative Structure—Activity Relationships of Mutagenic and Carcinogenic Aromatic Amines

Romualdo Benigni, Alessandro Giuliani, Rainer Franke, Andreas Gruska

Journal:

Year:

2000

File:

PDF, 26 KB

2000

10

ChemInform Abstract: Nonlinear Signal Analysis Methods in the Elucidation of Protein Sequence—Structure Relationships

Alessandro Giuliani, Romualdo Benigni, Joseph P. Zbilut, Charles L. Webber Jr., Paolo Sirabella, Alfredo Colosimo

Journal:

Year:

2002

File:

PDF, 25 KB

2002

11

Looking for an Unambiguous Geometrical Definition of Organic Series from 3-D Molecular Similarity Indices.

Marina Cotta-Ramusino, Romualdo Benigni, Laura Passerini, Alessandro Giuliani

Journal:

Year:

2003

File:

PDF, 73 KB

2003

12

Structure—Activity Relationship Studies of Chemical Mutagens and Carcinogens: Mechanistic Investigations and Prediction Approaches

Romualdo Benigni

Journal:

Year:

2005

File:

PDF, 8 KB

2005

13

Structure–activity relationships for the mutagenicity and carcinogenicity of simple and α-β unsaturated aldehydes

Romualdo Benigni, Laura Passerini, Andrea Rodomonte

Journal:

Environmental and Molecular Mutagenesis

Year:

2003

Language:

english

File:

PDF, 108 KB

english, 2003

14

Simple and α,β-unsaturated aldehydes: Correct prediction of genotoxic activity through structure–activity relationship models

Romualdo Benigni, Luigi Conti, Riccardo Crebelli, Andrea Rodomonte, Maria Rosaria Vari'

Journal:

Environmental and Molecular Mutagenesis

Year:

2005

Language:

english

File:

PDF, 150 KB

english, 2005

15

Mechanistic QSAR of aromatic amines: New models for discriminating between homocyclic mutagens and nonmutagens, and validation of models for carcinogens

Romualdo Benigni, Cecilia Bossa, Tatiana Netzeva, Andrea Rodomonte, Ivanka Tsakovska

Journal:

Environmental and Molecular Mutagenesis

Year:

2007

Language:

english

File:

PDF, 183 KB

english, 2007

16

Structural motifs modulating the carcinogenic risk of aromatic amines

Romualdo Benigni, Andrew Worth, Tatiana Netzeva, Nina Jeliazkova, Cecilia Bossa, Andreas Gruska, Rainer Franke

Journal:

Environmental and Molecular Mutagenesis

Year:

2009

Language:

english

File:

PDF, 228 KB

english, 2009

17

Flexible use of qsar models in predictive toxicology: A case study on aromatic amines

Romualdo Benigni, Cecilia Bossa

Journal:

Environmental and Molecular Mutagenesis

Year:

2012

Language:

english

File:

PDF, 315 KB

english, 2012

18

Predicting chemical carcinogenesis in rodents: Commentary on the results of a workshop

Romualdo Benigni

Journal:

Environmental and Molecular Mutagenesis

Year:

1993

Language:

english

File:

PDF, 121 KB

english, 1993

19

Relationships among in vitro mutagenicity assays: Quantitative vs. qualitative test results

Romualdo Benigni, Cristina Andreoli, Alessandro Giuliani

Journal:

Environmental and Molecular Mutagenesis

Year:

1995

Language:

english

File:

PDF, 595 KB

english, 1995

20

On the constructive role of noise in spatial systems

Alessandro Giuliani, Alfredo Colosimo, Romualdo Benigni, Joseph P Zbilut

Journal:

Physics Letters A

Year:

1998

Language:

english

File:

PDF, 665 KB

english, 1998

21

Collaborative development of predictive toxicology applications

Barry Hardy, Nicki Douglas, Christoph Helma, Micha Rautenberg, Nina Jeliazkova, Vedrin Jeliazkov, Ivelina Nikolova, Romualdo Benigni, Olga Tcheremenskaia, Stefan Kramer, Tobias Girschick, Fabian Buchw

Journal:

Journal of Cheminformatics

Year:

2010

Language:

english

File:

PDF, 3.76 MB

english, 2010

22

Large contact surface interactions between proteins detected by time series analysis methods: Case study on C-phycocyanins

Alessandro Giuliani, Romualdo Benigni, Mauro Colafranceschi, Indu Chandrashekar, Sudha M. Cowsik

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2003

Language:

english

File:

PDF, 174 KB

english, 2003

23

Genotoxic activity of dichlorvos, trichlorfon and dichloroacetaldehyde

Gabriele Aquilina, Romualdo Benigni, Margherita Bignami, Angelo Calcagnile, Eugenia Dogliotti, Emiliana Falcone, Angelo Carere

Journal:

Pest Management Science

Year:

1984

Language:

english

File:

PDF, 251 KB

english, 1984

24

Toxicity Mode-of-action: Discrimination via Infrared Spectra And Eigenvalues of the Modified Adjacency Matrix

Anna Pino, Alessandro Giuliani, Romualdo Benigni

Journal:

Molecular Informatics

Year:

2003

Language:

english

File:

PDF, 290 KB

english, 2003

25

Relationships between in vitro mutagenicity assays

Benigni, Romualdo

Journal:

Year:

1992

Language:

english

File:

PDF, 637 KB

english, 1992

26

Letter to the editors: What kind of statistics for QSAR research?

Romualdo Benigni, A. Giuliani

Journal:

Molecular Informatics

Year:

1991

Language:

english

File:

PDF, 204 KB

english, 1991

27

EVE, a Distance Based Approach for Discriminating Nonlinearly Separable Groups

Romualdo Benigni

Journal:

Molecular Informatics

Year:

1994

Language:

english

File:

PDF, 390 KB

english, 1994

28

Toxicology of halogenated aliphatic hydrocarbons: structural and molecular determinants for the disturbance of chromosome segregation and the induction of lipid peroxidation

Riccardo Crebelli, Cristina Andreoli, Angelo Carere, Luigi Conti, Barbara Crochi, Marina Cotta-Ramusino, Romualdo Benigni

Journal:

Chemico-Biological Interactions

Year:

1995

Language:

english

File:

PDF, 1.15 MB

english, 1995

29

Quantiative structure-activity relationship (QSAR) studies in genetic toxicology: mathematical models and the “biological activity” term of the relationship

Romualdo Benigni, Alessandro Giuliani

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

1994

Language:

english

File:

PDF, 473 KB

english, 1994

30

Rodent carcinogenicity and toxicity, in vitro mutagenicity, and their physical chemical determinants

Romualdo Benigni, Cristina Andreoli

Journal:

Mutation Research/Reviews in Genetic Toxicology

Year:

1993

Language:

english

File:

PDF, 874 KB

english, 1993

31

Predicting chemical carcinogenesis in rodents: The state of the art in light of a comparative exercise

Romualdo Benigni

Journal:

Mutation Research/Environmental Mutagenesis and Related Subjects

Year:

1995

Language:

english

File:

PDF, 853 KB

english, 1995

32

DNA repair studies on diallate, triallate and sulfallate in human cell cultures

Romualdo Benigni, Eugenia Dogliotti, Emiliana Falcone, Angelo Calcagnile

Journal:

Mutation Research Letters

Year:

1982

Language:

english

File:

PDF, 245 KB

english, 1982

33

QSARs of aromatic amines: Identification of potent carcinogens

Rainer Franke, Andreas Gruska, Cecilia Bossa, Romualdo Benigni

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

2010

Language:

english

File:

PDF, 263 KB

english, 2010

34

O II.2 - O II.2 When and how should we perform QSAR analyses?

Romualdo Benigni

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

1997

Language:

english

File:

PDF, 110 KB

english, 1997

35

Profiles of chemically-induced tumors in rodents: quantitative relationships

Romualdo Benigni, Anna Pino

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

1998

Language:

english

File:

PDF, 246 KB

english, 1998

36

QSARS of mutagens and carcinogens: Two case studies illustrating problems in the construction of models for noncongeneric chemicals

Romualdo Benigni, Ann M. Richard

Journal:

Mutation Research/Genetic Toxicology

Year:

1996

Language:

english

File:

PDF, 1.37 MB

english, 1996

37

OpenTox predictive toxicology framework: toxicological ontology and semantic media wiki-based OpenToxipedia

Olga Tcheremenskaia, Romualdo Benigni, Ivelina Nikolova, Nina Jeliazkova, Sylvia E Escher, Monika Batke, Thomas Baier, Vladimir Poroikov, Alexey Lagunin, Micha Rautenberg, Barry Hardy

Journal:

Journal of Biomedical Semantics

Year:

2012

Language:

english

File:

PDF, 727 KB

english, 2012

38

Quantitative Structure-Based Modeling Applied to Characterization and Prediction of Chemical Toxicity

Romualdo Benigni, Ann M. Richard

Journal:

Year:

1998

Language:

english

File:

PDF, 180 KB

english, 1998

39

Social sexual inequality and sex difference in cancer incidence

Romualdo Benigni

Journal:

Environmental Research

Year:

2007

Language:

english

File:

PDF, 206 KB

english, 2007

40

Structure alerts for carcinogenicity, and the Salmonella assay system: A novel insight through the chemical relational databases technology

Romualdo Benigni, Cecilia Bossa

Journal:

Mutation Research/Reviews in Mutation Research

Year:

2008

Language:

english

File:

PDF, 537 KB

english, 2008

41

Carcinogenicity of the aromatic amines: from structure–activity relationships to mechanisms of action and risk assessment

Romualdo Benigni, Laura Passerini

Journal:

Mutation Research/Reviews in Mutation Research

Year:

2002

Language:

english

File:

PDF, 353 KB

english, 2002

42

The second National Toxicology Program comparative exercise on the prediction of rodent carcinogenicity: definitive results

Romualdo Benigni, Romano Zito

Journal:

Mutation Research/Reviews in Mutation Research

Year:

2004

Language:

english

File:

PDF, 162 KB

english, 2004

43

The first US National Toxicology Program exercise on the prediction of rodent carcinogenicity: definitive results

Romualdo Benigni

Journal:

Mutation Research/Reviews in Mutation Research

Year:

1997

Language:

english

File:

PDF, 238 KB

english, 1997

44

The Expanding Role of Predictive Toxicology: An Update on the (Q)SAR Models for Mutagens and Carcinogens

BENIGNI, ROMUALDO, NETZEVA, TATIANA I., BENFENATI, EMILIO, BOSSA, CECILIA, FRANKE, RAINER, HELMA, CHRISTOPH, HULZEBOS, ETJE, MARCHANT, CAROL, RICHARD, ANN, WOO, YIN-TAK, YANG, CHIHAE

Journal:

Journal of Environmental Science and Health Part C

Year:

2007

Language:

english

File:

PDF, 2.48 MB

english, 2007

45

Nonlinear Methods in the Analysis of Protein Sequences: A Case Study in Rubredoxins

Giuliani, Alessandro, Benigni, Romualdo, Sirabella, Paolo, Zbilut, Joseph P., Colosimo, Alfredo

Journal:

Biophysical Journal

Year:

2000

Language:

english

File:

PDF, 578 KB

english, 2000

46

Correlation between Gene Expression and Clinical Data through Linear and Nonlinear Principal Components Analyses: Muscular Dystrophies as Case Studies

Romualdi, Chiara, Giuliani, Alessandro, Millino, Caterina, Celegato, Barbara, Benigni, Romualdo, Lanfranchi, Gerolamo

Journal:

Omics A Journal of Integrative Biology

Year:

2009

Language:

english

File:

PDF, 14.56 MB

english, 2009

47

Computational prediction of drug toxicity: the case of mutagenicity and carcinogenicity

Romualdo Benigni

Journal:

Drug Discovery Today: Technologies

Year:

2004

Language:

english

File:

PDF, 140 KB

english, 2004

48

Structure–Activity models for chemical carcinogens

Romualdo Benigni

Journal:

Toxicology Letters

Year:

2009

Language:

english

File:

PDF, 44 KB

english, 2009

49

Investigating the Relationship between in Vitro–in Vivo Genotoxicity: Derivation of Mechanistic QSAR Models for in Vivo Liver Genotoxicity and in Vivo Bone Marrow Micronucleus Formation Which Encompass Metabolism

Mekenyan, Ovanes G., Petkov, Petko I., Kotov, Stefan V., Stoeva, Stoyanka, Kamenska, Verginia B., Dimitrov, Sabcho D., Honma, Masamitsu, Hayashi, Makoto, Benigni, Romualdo, Donner, E. Maria, Patlewicz

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 2.23 MB

english, 2012

50

Predictivity of QSAR

Benigni, Romualdo, Bossa, Cecilia

Journal:

Journal of Chemical Information and Modeling

Year:

2008

Language:

english

File:

PDF, 150 KB

english, 2008